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In vivo experiments display anatomically selective neurochemical outcomes of modafinil on monoaminergic techniques (de Saint Hilaire et al 2001; Ferraro et al 2002), and, notably, when modafinil increases TMN fos expression (Scammell et al 2000) and HAergic tone it's not able to exert this impact when administered specifically into your TMN (Ishizu

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